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	Provedor de dados BJMBR (1) BJPS (1) Autor Adibkia,Khosro (1) Cabrera,R.J. (1) Fattahi,Ali (1) Gargiulo,P.A. (1) Ghiasi,Mansoureh (1) Hosseinzadeh,Leila (1) Landa,A.I. (1) Mohammadi,Ghobad (1) Mohammadi,Pardis (1) Mais... Palavra-chave Prazosin (2) Drug delivery (1) Flutamide (1) Glutamate (1) Luteinizing hormone (1) N-methyl-D-aspartic acid (1) Nanoparticle (1) Noradrenergic transmission (1) PLGA (1) Prostate cancer (1) Sexual behavior (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Prazosin blocks the glutamatergic effects of N-methyl-D-aspartic acid on lordosis behavior and luteinizing hormone secretion in the estrogen-primed female rat BJMBR Landa,A.I.; Cabrera,R.J.; Gargiulo,P.A.. We have observed that intracerebroventricular (icv) injection of selective N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptor antagonists inhibits lordosis in ovariectomized (OVX), estrogen-primed rats receiving progesterone or luteinizing hormone-releasing hormone (LHRH). When NMDA was injected into OVX estrogen-primed rats, it induced a significant increase in lordosis. The interaction between LHRH and glutamate was previously explored by us and another groups. The noradrenergic systems have a functional role in the regulation of LHRH release. The purpose of the present study was to explore the interaction between glutamatergic and noradrenergic transmission. The action of prazosin, an alpha1- and alpha2b-noradrenergic antagonist, was studied... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sexual behavior; Glutamate; Luteinizing hormone; Noradrenergic transmission; Prazosin; N-methyl-D-aspartic acid. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300007 Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide BJPS Fattahi,Ali; Ghiasi,Mansoureh; Mohammadi,Pardis; Hosseinzadeh,Leila; Adibkia,Khosro; Mohammadi,Ghobad. In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1H-NMR. Flutamide-loaded nanoparticles were prepared by quasi-emulsion solvent diffusion technique. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency, and release properties. Also, the physicochemical properties of the nanoparticles were analyzed using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry, and Powder... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoparticle; PLGA; Flutamide; Prazosin; Prostate cancer; Drug delivery. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400609 Registros recuperados: 2 Primeira ... 1 ... Última

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